The long-term efficacy and safety outcomes of RHA® with
lidocaine are applicable to RHA® with mepivacaine and have shown
no significant impact on gel properties, including rheology and degradation
profile.
RHA® Collection of Fillers, by Teoxane
Approved Uses
The Teoxane RHA® Collection of resilient hyaluronic acid
(HA) fillers includes RHA Redensity® , RHA® 2,
RHA® 3 and RHA® 4.
RHA Redensity® is for injection into the facial tissue for
the correction of moderate to severe dynamic perioral rhytids; and RHA® 2 and RHA® 4 are for the correction of moderate to severe
dynamic facial wrinkles and folds, such as nasolabial folds, in adults
22 or older. RHA® 3 is for the correction of moderate to severe
dynamic facial wrinkles and folds, such as nasolabial folds, and also used
to augment lip fullness in adults 22 or older.
IMPORTANT SAFETY INFORMATION
Are there any reasons why I should not receive any RHA® injectable
gel formulation?
Do not receive if you have a history of multiple severe allergies or severe
allergic reactions; if you are allergic to lidocaine or mepivacaine or gram-positive
bacterial proteins; or if you have a bleeding disorder.
What precautions should I discuss with my doctor?
• Tell your doctor if you are pregnant or breastfeeding as the
safety of these products for use during pregnancy or while breastfeeding
has not been studied
• Tell your doctor if you have a history of excessive scarring,
keloid formations or pigmentation disorders, as use of these products
may result in additional scars or changes in pigmentation
• Tell your doctor if you are planning laser treatments or a
chemical peel, as there is a possible risk of inflammation at the
treatment site if these procedures are performed after treatment
• Tell your doctor if you are on immunosuppressive therapy used to
decrease your immune response, as use of these products may result in an
increased risk of infection
• Tell your doctor if you are using medications that can prolong
bleeding, such as aspirin, ibuprofen, or other blood thinners, as this
may increase bruising or bleeding at the injection site
• The safety and effectiveness of RHA® fillers in
areas other than those indicated have not been established in U.S.
clinical studies
• Patients who experience skin injury near the site of injection
with this product may be at a higher risk for side effects
• Minimize strenuous exercise, exposure to extensive sun or heat,
and alcoholic beverages within the first 24 hours following treatment
What are possible side effects?
The most commonly reported side effects included injection-site redness,
swelling, pain, tenderness, firmness, lumps/bumps, bruising, discoloration,
and itching.
One of the risks with using these products is unintentional injection
into a blood vessel, and while rare, the complications can be serious
and may be permanent. These complications, which have been reported for
facial injections, can include vision abnormalities, blindness, stroke,
temporary scabs, or permanent scarring.
Delayed-onset inflammation near the site of dermal filler injections is
one of the known side effects associated with dermal fillers. Cases of
delayed-onset inflammation have been reported to occur at the treatment
site following viral or bacterial illnesses or infections, vaccinations,
or dental procedures.
Typically, the reported inflammation was responsive to being treated or
resolved on its own.
As with all skin injection procedures, there is a risk of infection and
recurrence of herpetic eruptions.
To report a side effect with any RHA® product, please call
Revance at (877) 373-8669 or report online at safety.revance.com.
Please visit RHACollection.com or talk to your doctor for more information.
©2025 REVANCE. RHA® and RHA
Redensity® are registered trademarks of TEOXANE SA,
manufactured in Switzerland. The Teoxane RHA® Collection
is exclusively distributed by Revance®. All other
trademarks are the property of their respective owners.
Available by prescription only.
RHA-00220
